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For treatment of T2D amongst patients without pre-existing cardiovascular or renal complications who are not adequately controlled on metformin (with or without sulfonylurea), in order to reduce HbA1c levels, international [13] and Danish [14] guidelines recommend intensifying with anti-diabetic treatment options such as dipeptidyl peptidase-4 inhibitors (DPP4is), sodiumglucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs)

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A sterile 10 L pipette tip was used to create wounds, and areas of wound lines were observed and assessed by inverted microscope after 24 h

doi: 10.3389/fphar.2020.01169 77 HyserJ

The escalation schedule exists for a reason: it gives your body time to adapt to gastrointestinal changes like nausea and constipation while your GLP-1 receptors become increasingly responsive

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