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Clinically, Epi_2 tumors are associated with lymph-node metastasis and refractoriness to both immune-checkpoint blockade and anti-EGFR therapies ( Collectively, cuproptosis constitutes a tripartite regulatory circuittumor suppression, immune modulation, and drug sensitivityin OSCC

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In the end, SURMOUNT-4 is a trial that studies BW preservation in participants with obesity or overweight

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Interestingly, this was also associated with greater weight loss in response to another weight loss drug, phentermine-topiramate, although it is not clear whether the correlation to weight loss is with the starting body weight or the impaired satiation [40]