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Caroline Apovian, codirector of the Center for Weight Management and Wellness at Brigham and Womens Hospital in Boston, says that because compounded drugs are not reviewed for safety, quality, and effectiveness, there is potential for variation across compounded medications

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For example, recently it was reported that a rhubarb extract, Rhein, increasing the intestinal population of Bacteroidetes, mediates an increase in ileal GLP-1 producing cells, peripheral GLP-1(7-36) NH2 levels and improved glucose tolerance in diabetic db/db mice (395)