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The methyl donor for this reaction is S-adenosylmethionine (SAM or AdoMet) and the reaction is catalyzed by the enzyme guanidinoacetate N -methyltransferase

The solution is sold through 300 channel partners in 75 countries and used in over 190 countries

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It's remarkably active in the body, influencing thousands of genes involved in collagen production, wound healing, and new blood vessel growth