This is because, in comparison to GLP-1, semaglutide has two amino acid substitutions, which makes it less vulnerable to degradation by the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) [97] and gives it the distinct advantage of increased albumin affinity [96]
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Tirzepatide demonstrated superior efficacy compared to placebo and other common glucose-lowering therapies, including semaglutide 1 mg, dulaglutide, insulin degludec, and glargine
It belongs to a new generation of incretin-based compounds often called triple agonists because of their ability to simultaneously activate three distinct metabolic receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)
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Tirzepatide dose-dependently leads to clinically significant reductions in glycemic parameters and body weight and has been shown to have stronger effects in reducing these parameters than standard antidiabetic therapy
