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We shouldnt be surprised that they gain the weight back because, effectively, the semaglutide is influencing energy balance, so what the body takes in and what it takes out, in an artificial way. That doesnt mean the drug isnt helpful: Getting weight off people for a period of time is better than not having the weight off them at all, says Gately

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Li C-X, Liang S, Gao L, Liu H