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Studies suggest that a significant proportion of long-term metformin users may develop biochemical B12 deficiency, though estimates vary widely depending on the population studied, the duration of use, and the B12 threshold applied

Sun-Wang, J

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Animal studies involving BPC-157 usually undergo review to ensure that endpoints are meaningful and that discomfort is minimized where possible

doi: 10.1016/j.breast.2014.07.005 33 PinelliSArtiniPGBasileSObinoMERSergiampietriCGiannarelliDet al