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That human review is a key reason appeals can succeed

J Comp Neurol

For many years duodenal ulcers were thought to be caused by stress and lifestyle factors and treated with antacids

PMID: 29 AtzeniFGerratanaEFrancesco MasalaIBongiovanniSSarzi-PuttiniPRodrguez-CarrioJ

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This highlights the importance of M&A for these emerging therapeutics in an investment thesis, as such trials are much more feasible for large pharma companies than for biotech startups