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EFFECT OF GLP1 RECEPTOR AGONISTS IN PATIENTS ON SGLT2 INHIBITOR THERAPY As discussed earlier, the effect of a GLP-1 RA (efpeglenatide- not available) in patients on an SGLT-2 inhibitor was determined in the AMPLITUDE-O trial (312)

Unknown long-term effects are themselves a risk factor worth acknowledging

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4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

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