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injections of 10 nmol kg 1 semaglutide ( n = 6 mice and n = 3 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) for 5 days

Only after the completion of these studies can regulatory agencies determine whether the drug should be approved for medical use

Clinical trials revealed common side effects such as mild gastrointestinal issues, including nausea and diarrhea

While GLP-1 and GIP perform similar actions for blood sugar control and fat metabolism as semaglutide, retatrutide also activates GCG which primarily benefits gut health and nutrient absorption

Use should be combined with a reduced-calorie diet and increased physical activity

Kidney Failure Research indicates that in some cases, use of semaglutide contributes to kidney disease