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Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

The GAO recommends that public water systems provide clearer communication to residents about the risks of PFAS and proper disposal methods for PFAS-contaminated waste

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Effects on diastolic BP were not apparent, and thus, there was a significant reduction in pulse pressure

several large ones see no increase, and the absolute risk stays low