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Aging and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

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Bhutani MS, Ejaz S, Cazacu IM, Singh BS, Shafi M, Stroehlein JR, Mehran RJ, Walsh G, Vaporciyan A, Swisher SG , Hofstetter W

But when this insulin is called upon too frequently (a diet high in refined sugars, frequent snacking, a sugary breakfast), your cells become resistant: more and more insulin is needed for the same effect