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The intake of LC lowers the intramitochondrial acetyl-CoA to free CoA ratio, which promotes pyruvate dehydrogenase activity and glucose oxidation

Maintenance dose: 25 mg orally once daily for cardiovascular risk reduction and weight reduction in adults

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Vitamin D3 and zinc, when administered together, more effectively induce regulatory T cells and suppress IFN- production in mixed lymphocyte cultures compared to treatment with either Vitamin D3 alone

For DPP-4 activity assays, blood was collected before and 30 minutes or 1 hour after olive oil gavage, and activity was assessed using a fluorometric assay (substrate: 10 mM H-Gly-Pro-AMC HBr [Bachem, I-1225], standard: AMC [Bachem, Q-1025])