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The evidence from published intervention trials is consistent: T/T individuals receiving adequate 5-MTHF + B12 + B6 supplementation normalize plasma homocysteine to levels similar to C/C individuals, restore BH4 availability and endothelial function, and reduce the functional consequences of MTHFR impairment across most of the five longevity mechanisms described above

Glutamine supports immune function, gut health, and muscle recovery, while glutathione plays a role in antioxidant defenses, liver function, and aging

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