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Anti-Inflammatory Activity: Reduces TNF-alpha-induced IL-6 secretion in human dermal fibroblasts, with proposed anti-inflammatory benefits

The widely repeated claim that Dihexa is "seven orders of magnitude more potent than BDNF" traces to McCoy 2013 (PMID 23055539), the paper now under an Expression of Concern

Valcarcel B, Riva E, Pena C, von Glasenapp A, Leautaud V, Malpica L, Hildebrandt MAT

It incorporates aminoisobutyric acid (Aib) at the N-terminus, D-isomers at positions 3 and 4, and C-terminal amidation, which together confer metabolic stability and selective receptor activation

In comparison, it appears to reduce blood pressure and insulin resistance, 7

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