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Abstract Even though metagenomics have revolutionized the characterization of the human microbiome, detailed mechanistic studies are impracticable, as there is a dearth of robust culture collections

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Loren Pickart, who isolated GHK-CU in 1973, shows that the peptide increases production of Type I and Type III collagen while simultaneously upregulating matrix metalloproteinases, the enzymes that break down old, damaged collagen

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This seminal finding initiated over four decades of research establishing GHK-Cus regenerative properties across multiple tissue types and biological systems