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PMID 12185074

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As insulin resistance improves and weight decreases, many women notice: More regular menstrual cycles Improved or restored ovulation Reduced acne and excess hair growth Better energy and mood balance Lower risk of developing Type 2 diabetes This approach aligns with comprehensive OBGYN care that treats interconnected hormonal and metabolic factors together

Objectives of this narrative review are to summarize major meta-analysis findings on combination therapies, including real-world evidence (RWE) and cardiovascular outcome trials (CVOTs), with a focus on metabolic, cardiovascular, and renal endpoints