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A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonists were associated with increased risks of biliary disease compared to other diabetes medications, with higher risk observed at weight-loss doses and with longer duration of treatment

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Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients With Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis

Biomarker shifts (e.g., modest reductions in inflammatory and neurodegeneration markers) were observed but did not translate into clinical benefit

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