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It has historically been criticized because digestive enzymes can break down glutathione before it reaches circulation intact

GH exposure over 18 days increased the diameter of caprine preantral follicles, and using in vitro maturation protocols, led to the generation of healthy oocyte-cumulus complexes, production of more metaphase II oocytes, and better fertilization ability (15)

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The final choice depends on the patients age, activity level, health, imaging findings, and goals