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Results of a small, open-label (not placebo-controlled) study of PS128 showed that PS128 supplementation for 12 weeks in addition to anti-parkinsonian medication improved United Parkinson Disease Rating Scale (UPDRS) motor score and quality of life

CYP2C9 (Diclofenac Hydroxylation) and CYP2D6 (Dextromethorphan O-Demethylation) Assays The assays were performed as previously described [17], with some modification

This creates S-adenosylmethionine (SAM), which works as the universal cofactor for most biological methylation reactions [19]

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[1] In cultured mouse adipocytes, exposure to a methylquinolinium NNMT inhibitor raised intracellular NAD+ and SAM and lowered lipogenesis