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On the other hand, PERK induces translation initiation factor eIF2 phosphorylation (Han et al., 2013), which activates (ATF4) and CHOP and eventually culminates in apoptotic cell death

The involvement of oxidative stress in the breakdown of immune tolerance is another crucial mechanism in the pathogenesis of autoimmune diseases

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In fact, vitamin C can potentially enhance the effectiveness of glutathione

They also maintain sterility and minimize tissue trauma, which are vital for reproducible and reliable research outcomes