In the case of KATO-III cells, antiproliferative effects were shown at concentrations above 100 g/mL, while in LS174 cells, cytotoxic properties of bromelain were evidenced above 30 g/mL and its cytotoxicity increased with higher bromelain concentrations at 72h (81)
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The current review also explores the modulatory impact of polyphenols on the immune system, their influence on gut microbiota, and their implications across various life stages, from infancy to aging, as well as in athletic performance and dermatological health