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The international journal of biochemistry & cell biology , 37 (8), 1727-1737

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Untreated pyelonephritis progresses to sepsis in 10-20% of cases, particularly dangerous for pregnant women, diabetics, and immunocompromised patients who need immediate IV antibiotics

Vasaitis, T.S

Persistent or painful constipation should be medically evaluated

Another key area is metabolism, where markers such as HbA1c, fasting insulin, glucose, and uric acid are measured to assess blood sugar regulation and metabolic balance