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GLP-1 operates through multiple mechanisms, including reducing hunger, increasing a sense of fullness after meals, boosting energy expenditure, and improving insulin sensitivity

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Participants in this phase 3 trial saw remarkable outcomes at 80 weeks: a weight loss averaging 28.3% on the 12 mg dose

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Acknowledgements The authors would like to thank Henrik Kim Nielsen, Jens Heisterberg, and Karen Hauda (Novo Nordisk A/S, Denmark), and Gina MacNeil (Novo Nordisk Inc, United States) for review of, and input to, the manuscript, as well as Tina stergaard, Sisse Lakner Schmidt, and Michala Cronberg (Novo Nordisk A/S, Denmark) for help with physical stability analyses