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In 2019, Akakpo and colleagues reported protection of mice against toxic doses of APAP if fomepizole was given prior to APAP metabolism, with prevention of formation of APAP-protein adducts, increases in ROS, JNK activation, and necrosis, as would be expected from inhibition of CYP2E1

Subjects in the control group were injected with 30 mL saline twice daily as placebo control

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