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10.1016/j.mce.2021.111464 90 RenQ.SunQ.FuJ

These GI effects are typically temporary and most common during the first 4 to 8 weeks of treatment and often resolve as the body adjusts

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The observed interactions between the ECD and ECL1/3 in the inactive GLP-1R structure presented here agree with previous studies suggesting that the ECD stabilized an inactive state of the glucagon receptor through interactions with ECL1 and ECL3 20