This study is to explore a GSH-responsive AP probe-net, which can be activated by the abundant GSH in ATC cells to generate reactive alkoxyamine, and the formed alkoxyamine can trap AP sites and block the APE1 activity, leading to ATC cell death but less adverse effects towards normal cells
Serious Side Effects of GLP-1 Extreme complications might arise, but seldom
This results in elevated levels of steroid hormone production, especially androgens (male hormones like testosterone)
Weight loss is not only about eating less
Higgins JP, Thomas J, Chandler J, et al
Seek urgent medical attention (call 999 or attend A&E) if you experience: Severe chest pain or pressure , especially if radiating to the arm, jaw, or back Sudden severe breathlessness or difficulty breathing at rest Rapid or irregular heartbeat accompanied by dizziness or fainting Sudden weakness or numbness on one side of the body, face drooping, or speech problems (FAST: Face, Arms, Speech - Time to call 999) Contact NHS 111 or your GP if you notice: Progressive breathlessness during normal activities or when lying flat Unexplained swelling of ankles, legs, or abdomen Persistent fatigue or reduced exercise tolerance Rapid weight gain (2 kg or more over 3 days) without dietary changes Persistent palpitations or awareness of heartbeat Patients with pre-existing heart conditions should maintain regular follow-up appointments and inform their healthcare team if they notice any changes in their cardiac symptoms after starting Ozempic
