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The activation of NRF-2 in liver suppresses the synthesis of fatty acids [70], as observed in this study that included experimental feeding with 8-week-old NRF-2 null mice, and wild-type mice fed experimentally, observing the mRNA of sterol regulatory element-binding protein 1-c and fatty acid synthase as highly expressed in NRF-2 null [71], concluding that the protective action is afforded by the increase of AR

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However, the dominant side effects (nausea, diarrhea) come from the GLP-1 component, similar to other medications

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Laboratory Handling and Storage Protocols Powder Storage: Store at -20C to -80C in original sealed container (long-term storage) Room temperature storage acceptable for short-term use (L-Carnitine is stable) Protect from light exposure (minimal light sensitivity but good practice) Desiccated storage environment recommended to prevent moisture uptake Stability data available for 24+ months at -20C Hygroscopic nature requires resealing immediately after use Experimental Considerations: Working concentrations vary widely by application (0.1-10 mM for cell culture

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