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Patients enrolled in these studies typically had conditions such as chronic kidney disease, heart failure, and diabetes mellitus, and were often on RAAS inhibitors or other hyperkalemia-inducing medications [79,80,81]

Ethics declarations Ethics approval and consent to participate All procedures performed in studies involving human participants were in accordance with the ethical standards of Royan Institute and the 1964 Helsinki declaration and its later amendments or comparable ethical standards (Ethics approval number: IR.ACECR.ROYAN.REC.1397.156)

Clinical trial safety