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MRP proteins not only regulate GSH efflux, but also transport oxidized glutathione derivatives such as glutathione disulfide (GSSG), S-nitrosoglutathione (GS-NO) and glutathione-metal complexes, as well as other glutathione S-conjugates [77,79]

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The physiological pathway through which duloxetine exerts its effect may be through maintaining NE and 5HT levels in the CNS and Onufs nucleus

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