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Animal models reveal a better understanding of the antidepressant mechanism of neuromodulatory techniques such as deep brain stimulation (DBS), which is observed to work through activating brain derived neurotrophic factor (BDNF) related pathways

The peptides ability to influence melatonin release has also been documented, providing a mechanistic link between DSIP and circadian rhythm regulation that complements its direct effects on sleep architecture

Contraindications include personal history of medullary thyroid carcinoma, MEN 2, and certain diabetic retinopathy complications

Data are shown as the mean standard deviation (SD)