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866 Excitatory amino acid transporter 1(EAAT1) in senescent cartilage membranes can increase intracellular glutamate levels and activate the GSH synthesis system to combat ferroptosis
Pyocyanin-derived ROS oxidize the CF patients intracellular and extracellular GSH to form GSSG (21) and this decrease in GSH significantly alters host cell functions and cell death during the chronic stage of CF infection (Ran et al., 2003
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Wu J, Liu Z, Huang T, Wang Y, Song MM, Song T, et al