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The lack of superiority is probably attributable to the short follow-up period and high CVD risk in the enrolled subjects

GLP-1 Medications Semaglutide & Tirzepatide GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that work by mimicking the hormones your body naturally produces after eatingsignaling to the brain that you are full, slowing gastric emptying, and improving insulin sensitivity

10.1016/j.phrs.2019.104381 83 YangB.YuQ.ChangB.GuoQ.XuS.YiX.et al (2021)

Effects of Liraglutide on Weight Loss, Fat Distribution, and -Cell Function in Obese Subjects With Prediabetes or Early Type 2 Diabetes

The clearest way to interpret it is as a multi pathway study tool rather than a single mechanism product

For individuals with these variants, hydrogen water offers antioxidant support that bypasses their enzymatic limitation