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By boosting vitality and supporting a healthy circulatory system, IGF-1 LR3 plays a critical role in preserving long-term heart health and protecting against cardiovascular challenges

TRIUMPH-5 is a comparator study in type 2 diabetes, benchmarking retatrutide against an active comparator rather than placebo

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They can improve weight, insulin resistance, and menstrual regularity in selected patients, especially when combined with lifestyle modification or metformin

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tirzepatide adds GIP activity and often shows greater average weight loss in trials, but individual responses vary