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Consequently, Bbs5 / mice treated with semaglutide exhibited rapid weight loss (Figure 5E) and maintained a significant reduction in body weight, exceeding 10% compared with pretreatment levels (Figure 5F)

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Sustainable weight management is best achieved through a combination of dietary change, physical activity, and behavioural support, with pharmacotherapy used as an adjunct where clinically indicated and in line with NICE guidance