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Dabak DO, Kocaman N (2015) Effects of silymarin on methotrexate-induced nephrotoxicity in rats

The majority of evidence cited comes from in vitro studies, animal models, and limited Russian clinical research

However, if your needs are higher due to diet or absorption issues, a standalone B12 supplement may be advised

it is linked to regulation of cortisol and ACTH, potentially normalizing HPA axis function

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