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Probiotics as a therapeutic strategy in obesity and overweight: a systematic review

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Endocrinology 136 , 35853596 (1995)

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As demonstrated by oxyntomodulin, a weak endogenous agonist for GLP-1 receptor and glucagon receptor, a strategy that simultaneously stimulates both GLP-1 and glucagon receptors can reduce food intake while increasing energy expenditure, synergistically enhancing weight loss [105-107]

Including cyanocobalamin in the injection ensures adequate B12 replacement to prevent neurological complications and megaloblastic anemia that can develop over months of restricted intake