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As a result, increased stiffness triggers the translocation of the transcription factor co-activators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to the nucleus where they interact with the transcriptional enhanced associate domain (TEAD) family of transcription factors to induce gene expression [85]

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Further, several VABS-II domain scores such as adaptive behavior ( p = 0.03), socialization ( p = 0.03), maladaptive behavior ( p = 0.04) and internalizing behavior ( p = 0.02) also indicated significant changes

It was taken as E1 = 1 in the calculations

Science 321:208209 Sweeten TL, Posey DJ, Shankar S, McDougle CJ (2004) High nitric oxide production in autistic disorder: a possible role for interferon-gamma