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Thus, any comparison must be based on existing data from liraglutide's phase 3 trials and retatrutide's phase 2 trials: According to a 2016 systematic review of 43 randomized trials, liraglutide has shown significant benefits for T2D, with doses ranging from 1.2-1.8mg/daily leading to HbA1c decreases between -0.9% and -2.2% over six months
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The SELECT trial reported a 20% reduction in major adverse cardiovascular events with semaglutide versus placebo in patients with overweight/obesity and established cardiovascular disease, without diabetes [34] [35]
To date, much of the research on the effects of semaglutide on alcohol consumption has involved animal studies, or observational studies with humans
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