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In model experiments in pigs, they demonstrated that it was possible to completely protect infused GLP-1 against DPP-4 mediated degradation, and that this protection resulted in marked increase in the insulin response to glucose and GLP-1 (102)

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Additionally, studies have indicated that GLP-1RAs may directly stimulate acinar cells, leading to increased pancreatic enzyme levels and a potential pathway for the development of pancreatitis 14,15

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334 Hence, GIPR activation-based therapies may have the potential for bone pathology treatment