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showed that during intestinal inflammation, the GVB is disrupted, thus determining a state of bacterial product translocation and systemic inflammation, eventually leading to the propagation of inflammation to the brain, while the vascular barrier in the choroid plexus shuts down, helping protect the brain from inflammation but also potentially impairing some brain functions and causing anxiety [42]

Clinical Safety Data Clinical research involving approximately 900 participants across six human studies provides substantial safety data

Oxidative stress leads to lipid peroxidation, which causes cellular damage and impairs lipid metabolism [90]