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Endothelial cells also contribute to IRI-AKI pathology by enhancing endothelium-leukocyte interactions, activating leukocytes, obstructing capillaries and postcapillary venules, and increasing microvascular permeability

It should be discontinued if eGFR falls below 30 mL/min/1.73 m and should not be initiated if eGFR is below 45 mL/min/1.73 m [109]

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For instance, improper incineration and disposal of hospital waste releases volatile compounds into the air and leachate into groundwater, causing respiratory issues and increasing cancer risk among nearby populations [71]