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Despite its strengths as a well-designed human intervention study, the follow-up period was relatively short, limiting conclusions regarding durability of glycemic improvements, long-term insulin resistance trajectories, or effects on clinically meaningful outcomes such as diabetes progression, medication requirements, or cardiovascular risk
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Users and researchers have documented effects across several domains of health and performance, though it bears mentioning that much of this evidence comes from animal studies, small human trials, or anecdotal reports rather than large-scale clinical trials
Altogether, while RNA therapy holds great potential, these multifaceted obstacles contribute to its clinical failure in certain cancer patients, necessitating improved targeting strategies, personalized approaches, and combination therapies to enhance efficacy and overcome resistance
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