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6 Knockdown of CrAT or CrOT decreases histone acetylation and the acetyl-CoA pool and increases sensitivity to olaparib

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433 Moreover, it has also been documented that p300 in association with CREB suppress lipid peroxidation by binding to the GPX4 (glutathione peroxidase 4) promoter region, which further inhibits ferroptosis in lung adenocarcinoma