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In a double-blind, placebo-controlled, phase 2b trial, patients with diabetes were administered all doses of tirzepatide, dulaglutide, or placebo

In addition, the insulin release stimulated by GLP-1 is glucose-dependent

Unlike brick-and-mortar weight-loss clinics, Hers and Hims offer everything online, mainly in a cash pay model

Most advanced is tirzepatide, a GIP-GLP-1 co-agonist, which was recently approved for diabetes therapy in the US

PlexusDx offers the Precision Peptide Genetic Test ($99 add-on after first month of treatment), which maps 14 metabolic pathways and 49 peptides to describe the pathway-level variants involved

Most side effects reported in clinical trials have been mild to moderate and may improve as the body adjusts during dose escalation