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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

While the FDA allows compounding under specific shortage conditions, the agency doesnt review or approve these customized drugs for safety, purity, or efficacy

For adults over 40, whose sleep architecture is already more fragile than at younger ages, this is not a trivial consideration

Innovative designs incorporating active comparators, adaptive frameworks, and biomarker-driven endpoints (e.g., CSF/serum NfL, p-tau, microglial PET, synaptic markers) will be critical to generate interpretable efficacy signals

2026 03 18 glutatin y cncer Llus Espinosa EN Llus Espinosa Coordinator of the Research Group on Molecular Mechanisms of Cancer and Stem Cells at IMIM-Hospital del Mar The study by Hecht and colleagues is impeccably conducted, and its experimental rigour allows for a solid demonstration of the importance of extracellular glutathione as a source of cysteine in breast tumours, at least in the murine models analysed