One theory is that mental health problems are caused by high homocysteine levels (vitamin B12 is needed to break down this chemical)
Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake
doi: 10.1038/nature25986 79 WeissJMDaviesLCKarwanMIlevaLOzakiMKChengRYet al
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However, these effects were completely blunted in NaCl-restricted subjects, despite GH-stimulated renal ammonia production as suggested by increases in urine pH, and could be restored after changing back to a normal NaCL diet
The MTHFR mutation is a common genetic variation that affects how your body processes folate and produces methylfolate