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Glycolytic and gluconeogenic metabolites and expression of genes involved in glucose metabolism including glucose-6-phosphate, G6pc , and Pck1 , demonstrated high glucose dose sensitivity

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Its anticancer activity stems from two principal mechanisms: epigenetic remodeling via altered histone methylation, and direct modulation of cellular energetics and proliferation

MD, Johannes FE, Mann MD, Nauck MA, Steven MD, Nissen E, Pocock MDS, Neil PD, Poulter R, Lasse FMS, Ravn S, Steinberg MDPDWM, Mette Stockner MD, Bernard Zinman MD, Bergenstal MDRM, M.D., and, Buse JB

All findings are limited to laboratory and experimental settings and do not indicate clinical performance