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Decreased insulin-mediated suppression of adipocyte lipolysis has been reported in obese rats (118) as well as in women with visceral obesity (3, 54), although several other studies in humans report that the antilipolytic effects of insulin are well conserved, even in subjects with highly impaired insulin-mediated glucose regulation (7, 8, 11, 52)

Ammori BJ, Fitzgerald P, Hawkey P, et al

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These properties suggest it might be studied in contexts of cellular age-associated degeneration, neuroinflammation, ischemia-reperfusion research, or chronic inflammatory disorders

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