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SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

At 3 days after adding FOXO4-DRI (25 M) in medium, few SA--gal-positive cells were observed in both keloid fibroblasts and normal skin fibroblasts (Fig

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